Alt text Alt text Alt text Alt text

The Beauty within...

Refineé Age-Reversing Skin Care was created in the belief that the secret to youthful beauty lies within. Not just in the soul and spirit, but also just beneath your skin’s surface. Recovering and protecting that beauty is what defines Refineé products. Each luxurious cleanser, brightening exfoliant, soothing repairing cream and firming serum is make of a remarkable new fusion of the most advanced ingredient technology in harmony with precious protective botanical extracts from the earth and ocean.

Features and Benefits

Refineé skin care has combined science and nature by combining peptides and natural botanicals.

Peptides: are small chains of amino acids which are the building blocks of the living tissues.
Natural botanicals:
Green Tea- repairs cell damage
Ginko Biloba- increases circulation
Comfrey- rejuvenates cells
Arnica- known for its antibacterial and anti-aging properties
Chamomile- soothes skin
So by pairing peptides with these natural plant extracts we have created the PEP-SYN Complex.

Refineé will reveal the youthful beauty that is waiting to be re-discovered in you. Experience the phenomenal visible results now and for years to comeTHE EXCLUSIVE REFINEÉ PEP-SYN™ COMPLEX

Only Refineé Age Reversing Skin Care contains the exclusive, innovative PEP-SYN™ COMPLEX that pairs clinically proven patented anti-aging peptides with carefully selected plant extracts to keep skin soothed and hydrated while dramatically working to reverse the aging process.

Refineé Age Reversing Skin Care uses the most exceptional quality natural botanical extracts from plants and sea life. Ancient skin care utilized these healing and revitalizing ‘phyto’ ingredients combined with rejuvenating essential aromatic oils to keep skin radiantly healthy. Select botanicals that are soothing and highly antioxidant include Japanese Green Tea, Gingko Biloba, Comfrey, Aloe, Arnica, Chamomile, and Pomegranate. Natural essential aromatic oils of Lavender, Orange, Grapefruit and Tangerine are calming to both skin and psyche.

the science of youthful skin

Refinée skin research has identified important clinically proven peptides that are laboratory tested and proven to powerfully benefit your skin in the age-reversing process.

The innovative Refineé PEP-SYN™ COMPLEX pairs patented peptides that have clinically proven anti-aging benefits with complementary plant extracts that have century-proven healing power to create optimal age-reversing potency while keeping your skin soothed and hydrated. Your Refineé beauty ritual will help your skin behave like healthy, young skin that has not experienced the ravages of stress and time.

Matrixyl 3000 ® in our AGE RECOVERY CREAM helps reconstruct the deepest skin layers and activates your skin’s natural DNA to increase cellular repair. Enhances collagen production for smoother, plumper more youthful appearing skin. Greatly improves elasticity and tone.

Dermaxyl® in our award-winning ANTI-AGING EYE TREATMENT peptides stimulates cell communication and promotes the repair of age related skin damage. Prevents and repairs wrinkles while smoothing skin’s surface for a more youthful appearance with initial use.

Regu®Age in our ANTI-PUFF BRIGHTENING GEL from natural purified soy and rice peptides improves micro-circulation in skin to help prevent darkness especially in the eye area. Reduces the aging effect that free radicals have on skin’s natural collagen and elastin to prevent lines and wrinkles and keep skin tone firm.

Argireline® in our LINE STOP is a powerful natural peptide (Acetyl Hexapeptide-3) that helps inhibit the formation of the SNARE Complex to help prevent the formation of new wrinkles and reduce the depth of existing facial lines and wrinkles. This ingredient mimics the effect of surgical Botox treatments.

Matrixyl 3000 is a synthetic pentapeptide (Palmitoyl-Lys-Thr-Thr-Lys-Ser) that mimics a fragment of Procollagen Type I by stimulating the matrix molecules (Collagen I, III and IV and Fibronectin) to reduce the appearance of wrinkles.

Anti-wrinkling and lifting effect. 45% less deep wrinkles after 2 months!
Matrixyl(tm) 3000 contains twp matrikines(tm), Pal-GHK and Pal-GQPR which act in synergy to restore and maintain skin’s youthful appearance. These matrikines which are messengers of cutaneous restructuration and repair.
They can used in formulations for: anti-aging, face-lifting and wrinkle treatment products; suitable for gels, serums, lotions and creams.

DERMAXYL, a new anhydrous ingredient based on peptide technology, which utilizes a Matrikine-Ceramide 2 concept to combat aging and smooth out wrinkles. Dermaxyl - stimulates cell communication and then repairs the age related skin damage.
How can our serums with peptides do all this? Available through a new peptide technology available only with 21 st century technology. Palmitoyl oligopeptide (Dermaxyl) is one of the most potent anti-aging ingredients available today. Daily use of products formulated with Dermaxyl produce results similar to retinoic acid and retinol, and, very importantly, does so without the irritation these products and alpha hydroxy (fruit/glycolic) acid-based formulations often cause.

DERMAXYL smoothes out wrinkles while strengthening the skin’s natural barrier function. Its activity is based on peptide technology and tilizes a Matrikine- Ceramide 2 concept to combat the signs of aging. DERMAXYL’s activity was evaluated in a liquid foundation and showed a dramatic anti-wrinkling effect.
DERMAXYL, a new anhydrous ingredient from Sederma based on peptide technology, utilizes a Matrikine-Ceramide 2 concept to combat aging and smooth out wrinkles. Wrinkles are the founds of time that result from various internal and external factors that impair the quality of the epidermis and dermis. In vitro studies show that the Matrikine in DERMAXYL helps attract cells to sites that need repair and contributes to the reconstruction of the dermis. Ceramide 2 strengthens and repairs the skin’s barrier. It improves cell cohesion, enhancing water retention and reducing skin dryness.

Clinical Study:
Pigmented products tend to accentuate the appearance of wrinkles and skin dryness rather than mask them. That’s why we used a foundation to evaluate the anti-wrinkling efficacy of DERMAXYL.

After only applying it once a day, for 56 days the results were dramatic:

  • Volume of main wrinkle reduced on average by 13.7%- and reached as much as 36%!
  • Depth of main wrinkle reduced on average by 10.1%- and as much as 27%!
  • Surface occupied by deep wrinkles reduced on average by 40.3%-...
    and as much as 98%!
  • Surface occupied by medium wrinkles reduced on average by 24.5%-... and as much as 86%!


  • 75% of the volunteers stated that the product SMOOTHES the skin
  • 52% observed a decrease in wrinkles and crows feet.
  • DERMAXYL is recommended to be used at least 2 % in all skin care products (creams, lotions, serums) including color cosmetics.
  • DERMAXYL is Patent Pending.

This popular Acetyl Hexapeptide-3 is used in formulas as a wrinkle preventative as well as a wrinkle reducer as an alternative to injections.
Acetyl Hexapeptide-3 is a mimic of the N-terminal end of SNAP-25, one of three proteins (known as the SNARE complex) that are essential for neurotransmitter release at the synopsis, which is the chemical signal for a muscle to contract.
As a wrinkle reducer, studies have shown that Acetyl Hexapeptide-3 at a 10% concentration was able to significantly decrease the depth of wrinkles after 30 days of treatment. The mechanism by which Acetyl Hexapeptide-3 is able to accomplish this is related to the ways in which Acetyl Hexapeptide-3 is able to assist wrinkle prevention.

Acetyl Hexapeptide-3 performs this activity in two distinct ways:
The first way Acetyl Hexapeptide-3 acts as a wrinkle preventative is by competing with SNAP-25 for a position in the SNARE complex. This destabilizes the SNARE complex, preventing the vesicle from releasing neurotransmitters efficiently, and therefore attenuating muscle contraction. This causes a reduction in facial muscle contraction, which is believed to help prevent the long-term formation of lines and wrinkles.

The second way that Acetyl Hexapeptide-3 acts as a wrinkle preventative is by reducing the release of catecholamines (the overproduction of which is known to induce the formation of wrinkles and fine lines in the skin), specifically adrenaline and noradrenaline.

Acetyl Hexapeptide-3 is non-toxic and well tolerated by the skin.